Version 5.4
Mus musculus Gene: Gamt
Summary
InnateDB Gene IDBG-173403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gamt
Gene Name guanidinoacetate methyltransferase
Synonyms AA571402; Spintz1
Species Mus musculus
Ensembl Gene ENSMUSG00000020150
Encoded Proteins
IDBP-173405
guanidinoacetate methyltransferase
IDBP-271035
guanidinoacetate methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130005:
The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80258151-80261012
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000020359 ENSMUSP00000020359
ENSMUST00000105363 ENSMUSP00000101002
ENSMUST00000148615
ENSMUST00000144798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030731 guanidinoacetate N-methyltransferase activity
Biological Process
GO:0006601 creatine biosynthetic process
GO:0007283 spermatogenesis
GO:0009887 organ morphogenesis
GO:0032259 methylation
GO:0040014 regulation of multicellular organism growth
Cellular Component
GO:0005902 microvillus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130005
View Gene Order
ENSBTAG00000004112
Not yet available
Pathways
NETPATH
REACTOME
REACT_239426
Creatine metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_813
Creatine metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_207339
Creatine metabolism pathway
REACT_219139
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_010255 XM_006513221
OMIM
CCDS CCDS35976
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca