InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xpc

Summary

InnateDB Gene

IDBG-170258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xpc

Gene Name

xeroderma pigmentosum, complementation group C

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030094

Encoded Proteins

IDBP-170260

xeroderma pigmentosum, complementation group C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154767:
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:91489305-91515884

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032182	ENSMUSP00000032182
ENSMUST00000150279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0000715	nucleotide-excision repair, DNA damage recognition
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0010224	response to UV-B
GO:0031573	intra-S DNA damage checkpoint
GO:0042493	response to drug
GO:1901990	regulation of mitotic cell cycle phase transition