InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Txk

Summary

InnateDB Gene

IDBG-170081.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txk

Gene Name

TXK tyrosine kinase

Synonyms

A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054892

Encoded Proteins

IDBP-253524

TXK tyrosine kinase

IDBP-628363

TXK tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074966:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:72695978-72752773

Strand

Reverse strand

Band

C3.2

Transcripts

ENSMUST00000113604	ENSMUSP00000109234
ENSMUST00000169534	ENSMUSP00000129397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001816	cytokine production
GO:0001865	NK T cell differentiation
GO:0002250	adaptive immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007202	activation of phospholipase C activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0032729	positive regulation of interferon-gamma production
GO:0046777	protein autophosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway