InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gjb2

Summary

InnateDB Gene

IDBG-168253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gjb2

Gene Name

gap junction protein, beta 2

Synonyms

AI325222; Cnx26; Cx26; Gjb-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046352

Encoded Proteins

IDBP-168255

gap junction protein, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165474:
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50%% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:57098600-57104702

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055698

ENSMUSP00000054343

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity
GO:0005515	protein binding

Biological Process

GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0007605	sensory perception of sound
GO:0030539	male genitalia development
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0034599	cellular response to oxidative stress
GO:0044752	response to human chorionic gonadotropin
GO:0046697	decidualization
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction