Version 5.4
Mus musculus Gene: Ube2k
Summary
InnateDB Gene IDBG-166759.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2k
Gene Name ubiquitin-conjugating enzyme E2K
Synonyms AW492011; D5Ertd601e; E2-25k; Hip2; Hypg; Lig
Species Mus musculus
Ensembl Gene ENSMUSG00000029203
Encoded Proteins
IDBP-166761
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
IDBP-400918
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
IDBP-539575
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078140:
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington\'s disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65537233-65598988
Strand Forward strand
Band C3.1
Transcripts
ENSMUST00000031105 ENSMUSP00000031105
ENSMUST00000122141 ENSMUSP00000113645
ENSMUST00000142407 ENSMUSP00000122471
ENSMUST00000131873
ENSMUST00000146799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078140
View Gene Order
ENSBTAG00000020175
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z4U3
UniProt Splice Variant
Entrez Gene 53323
UniGene Mm.319512 Mm.412674 Mm.418613 Mm.457136
RefSeq NM_016786
OMIM
CCDS CCDS39098
HPRD
IMGT
MGI ID MGI:1858216
MGI Symbol Ube2k
EMBL AC112263 AC136513
GenPept
RNA Seq Atlas 53323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca