InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ripk3

Summary

InnateDB Gene

IDBG-165974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ripk3

Gene Name

receptor-interacting serine-threonine kinase 3

Synonyms

2610528K09Rik; AW107945; Rip3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022221

Encoded Proteins

IDBP-165976

receptor-interacting serine-threonine kinase 3

IDBP-620282

receptor-interacting serine-threonine kinase 3

IDBP-716471

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22123964

Ripk3 forms a complex with Ticam1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in Ripk3-dependent but TNF-independent necrosis in macrophages.

PMID 22423968

Ripk3 interacts with Zbp1 to mediate virus-induced necrosis.

PMID 25367573

Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.

InnateDB Annotation from Orthologs

Summary

PMID 22123964

[Homo sapiens] RIPK3 forms a complex with TICAM1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in RIPK3-dependent but TNF-independent necrosis in macrophages. (Demonstrated in mouse)

PMID 22423968

[Homo sapiens] RIPK3 interacts with ZBP1 to mediate virus-induced necrosis. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129465:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55784996-55788857

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022830	ENSMUSP00000022830
ENSMUST00000168716	ENSMUSP00000126306
ENSMUST00000178399	ENSMUSP00000137278

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0001914	regulation of T cell mediated cytotoxicity
GO:0002819	regulation of adaptive immune response
GO:0006468	protein phosphorylation
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0010922	positive regulation of phosphatase activity
GO:0016032	viral process
GO:0032147	activation of protein kinase activity
GO:0032649	regulation of interferon-gamma production
GO:0033077	T cell differentiation in thymus
GO:0038061	NIK/NF-kappaB signaling
GO:0043029	T cell homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0046006	regulation of activated T cell proliferation
GO:0046777	protein autophosphorylation
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048538	thymus development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0051347	positive regulation of transferase activity
GO:0051351	positive regulation of ligase activity
GO:0051353	positive regulation of oxidoreductase activity
GO:0060545	positive regulation of necroptotic process
GO:0070235	regulation of activation-induced cell death of T cells
GO:0070266	necroptotic process
GO:0090312	positive regulation of protein deacetylation
GO:1990000	amyloid fibril formation
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2000452	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway