Version 5.4
Mus musculus Gene: Mmp11
Summary
InnateDB Gene IDBG-164112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmp11
Gene Name matrix metallopeptidase 11
Synonyms ST3; Stmy3
Species Mus musculus
Ensembl Gene ENSMUSG00000000901
Encoded Proteins
IDBP-164114
matrix metallopeptidase 11
IDBP-401062
matrix metallopeptidase 11
IDBP-541929
matrix metallopeptidase 11
IDBP-535398
matrix metallopeptidase 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099953:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP\'s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75923222-75932502
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000000924 ENSMUSP00000000924
ENSMUST00000120281 ENSMUSP00000112940
ENSMUST00000132869 ENSMUSP00000120800
ENSMUST00000152222 ENSMUSP00000116279
ENSMUST00000133897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0071711 basement membrane organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099953
View Gene Order
ENSBTAG00000006108
Not yet available
Pathways
NETPATH
REACTOME
REACT_199000
Activation of Matrix Metalloproteinases pathway
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q02853
TrEMBL Q3UQT3 Q6GXA0
UniProt Splice Variant
Entrez Gene 17385
UniGene Mm.4561 Mm.488085
RefSeq NM_008606 XM_006513318
OMIM
CCDS CCDS23937
HPRD
IMGT
MGI ID MGI:97008
MGI Symbol Mmp11
EMBL AK142169 AY622971 CH466553 Z12604
GenPept AAT46402 BAE24956 CAA78248 EDL31869 EDL31870
RNA Seq Atlas 17385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca