InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bcr

Summary

InnateDB Gene

IDBG-162464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcr

Gene Name

breakpoint cluster region

Synonyms

5133400C09Rik; AI561783; AI853148; mKIAA3017

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009681

Encoded Proteins

IDBP-626731

breakpoint cluster region

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186716:
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:75060896-75184923

Strand

Forward strand

Band

Transcripts

ENSMUST00000164107

ENSMUSP00000126377

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042472	inner ear morphogenesis
GO:0043314	negative regulation of neutrophil degranulation
GO:0043547	positive regulation of GTPase activity
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050885	neuromuscular process controlling balance
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome