InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Srsf5

Summary

InnateDB Gene

IDBG-154042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srsf5

Gene Name

serine/arginine-rich splicing factor 5

Synonyms

Sfrs5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021134

Encoded Proteins

IDBP-620987

serine/arginine-rich splicing factor 5

IDBP-260445

serine/arginine-rich splicing factor 5

IDBP-260447

serine/arginine-rich splicing factor 5

IDBP-260449

serine/arginine-rich splicing factor 5

IDBP-260451

serine/arginine-rich splicing factor 5

IDBP-789088

serine/arginine-rich splicing factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:80945504-80950507

Strand

Forward strand

Band

Transcripts

ENSMUST00000094693	ENSMUSP00000131323
ENSMUST00000110356	ENSMUSP00000105985
ENSMUST00000110354	ENSMUSP00000105983
ENSMUST00000110352	ENSMUSP00000105981
ENSMUST00000110351	ENSMUSP00000105980
ENSMUST00000133783
ENSMUST00000153056
ENSMUST00000152662
ENSMUST00000138434	ENSMUSP00000138632
ENSMUST00000151968
ENSMUST00000125814
ENSMUST00000151036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0009611	response to wounding
GO:0051726	regulation of cell cycle