Version 5.4
Mus musculus Gene: Ift140
Summary
InnateDB Gene IDBG-150427.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ift140
Gene Name intraflagellar transport 140
Synonyms AI661311; mKIAA0590; Tce5; Wdtc2
Species Mus musculus
Ensembl Gene ENSMUSG00000024169
Encoded Proteins
IDBP-150429
intraflagellar transport 140 homolog (Chlamydomonas)
IDBP-534685
intraflagellar transport 140 homolog (Chlamydomonas)
IDBP-539618
intraflagellar transport 140 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187535:
This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25016091-25099495
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000024983 ENSMUSP00000024983
ENSMUST00000137386 ENSMUSP00000116163
ENSMUST00000151776
ENSMUST00000142000
ENSMUST00000156945 ENSMUSP00000116689
ENSMUST00000140692
ENSMUST00000153895
ENSMUST00000139300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0035721 intraciliary retrograde transport
GO:0042384 cilium assembly
GO:0048705 skeletal system morphogenesis
GO:0060041 retina development in camera-type eye
GO:0060271 cilium morphogenesis
GO:0061512 protein localization to cilium
GO:0072001 renal system development
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005929 cilium
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0072372 primary cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187535
View Gene Order
ENSBTAG00000007245
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.32802
RefSeq NM_134126 XM_006523402 XM_006523403 XM_006523404 XM_006523408
OMIM
CCDS CCDS28505
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca