InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Six4

Summary

InnateDB Gene

IDBG-148183.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Six4

Gene Name

sine oculis-related homeobox 4

Synonyms

AI047561; AREC3; TrexBF

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034460

Encoded Proteins

IDBP-148185

sine oculis-related homeobox 4 homolog (Drosophila)

IDBP-713854

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100625:
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:73099609-73113456

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043208	ENSMUSP00000036150
ENSMUST00000175693	ENSMUSP00000135699

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0008582	regulation of synaptic growth at neuromuscular junction
GO:0010468	regulation of gene expression
GO:0032880	regulation of protein localization
GO:0042472	inner ear morphogenesis
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048538	thymus development
GO:0048699	generation of neurons
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0048856	anatomical structure development
GO:0051451	myoblast migration
GO:0072075	metanephric mesenchyme development
GO:0072095	regulation of branch elongation involved in ureteric bud branching
GO:0072107	positive regulation of ureteric bud formation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000100625

View Gene Order

Cross-References

SwissProt

TrEMBL

H3BL91

UniProt Splice Variant

Entrez Gene

20474

UniGene

Mm.249575 Mm.382400 Mm.418538 Mm.465027 Mm.487050

RefSeq

NM_011382 XM_006515632

OMIM

CCDS

CCDS25974

HPRD

IMGT

MGI ID

MGI:106034

MGI Symbol

Six4

EMBL

AC159274

GenPept

RNA Seq Atlas

20474