Version 5.4
Mus musculus Gene: Skap2
Summary
InnateDB Gene IDBG-147582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Skap2
Gene Name src family associated phosphoprotein 2
Synonyms 2610021A10Rik; AA960083; BB137539; mSKAP55R; RA70; Saps; Scap2; SKAP-HOM
Species Mus musculus
Ensembl Gene ENSMUSG00000059182
Encoded Proteins
IDBP-147584
src family associated phosphoprotein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005020:
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:51859166-52012549
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000078214 ENSMUSP00000077342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0042113 B cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005020
View Gene Order
ENSBTAG00000005650
Not yet available
Pathways
NETPATH
REACTOME
REACT_215628
Signal regulatory protein (SIRP) family interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_215402
Signal regulatory protein (SIRP) family interactions pathway
REACT_206475
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3UND0
TrEMBL
UniProt Splice Variant
Entrez Gene 54353
UniGene
RefSeq NM_018773
OMIM
CCDS CCDS20137
HPRD
IMGT
MGI ID MGI:1889206
MGI Symbol Skap2
EMBL AB014485 AF051324 AK076000 AK144289 BC003711
GenPept AAC99297 AAH03711 BAA77253 BAC36111 BAE25817
RNA Seq Atlas 54353

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca