Version 5.4
Homo sapiens Gene: CRK
Summary
InnateDB Gene IDBG-14664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRK
Gene Name v-crk sarcoma virus CT10 oncogene homolog (avian)
Synonyms CRKII; p38
Species Homo sapiens
Ensembl Gene ENSG00000167193
Encoded Proteins
IDBP-14668
v-crk sarcoma virus CT10 oncogene homolog (avian)
IDBP-231803
v-crk sarcoma virus CT10 oncogene homolog (avian)
IDBP-758790
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1420689-1463162
Strand Reverse strand
Band p13.3
Transcripts
ENST00000300574 ENSP00000300574
ENST00000398970 ENSP00000381942
ENST00000572145
ENST00000574295 ENSP00000459505
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 216 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 216 [view]
Protein-Protein 216 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging
GO:0042169 SH2 domain binding
GO:0045309 protein phosphorylated amino acid binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0030168 platelet activation
GO:0032319 regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035020 regulation of Rac protein signal transduction
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017776
View Gene Order
ENSBTAG00000005665
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_12002
ARMS-mediated activation pathway
REACT_508
Signal attenuation pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_11061
Signalling by NGF pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
epha_fwdpathway
EPHA forward signaling
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
ephbfwdpathway
EPHB forward signaling
rac1_pathway
RAC1 signaling pathway
endothelinpathway
Endothelins
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
pdgfrapathway
PDGFR-alpha signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.461896 Hs.621952
RefSeq NM_005206 NM_016823
HUGO
OMIM
CCDS CCDS11002 CCDS45561
HPRD 01267
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca