Mus musculus Gene: Cdc45 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-142237.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Cdc45 | ||||||||||||||||||||||
Gene Name | cell division cycle 45 | ||||||||||||||||||||||
Synonyms | Cdc45l | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000000028 | ||||||||||||||||||||||
Encoded Proteins |
cell division cycle 45 homolog (S. cerevisiae)
cell division cycle 45 homolog (S. cerevisiae)
cell division cycle 45 homolog (S. cerevisiae)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000093009:
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 16:18780447-18811987 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Activation of the pre-replicative complex pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
Activation of ATR in response to replication stress pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
S Phase pathway
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KEGG |
Cell cycle pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Activation of ATR in response to replication stress pathway
Unwinding of DNA pathway
Activation of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Cell Cycle Checkpoints pathway
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KEGG |
Cell cycle pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.1248 | ||||||||||||||||||||||
RefSeq | NM_001161623 NM_009862 XM_006521744 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28027 CCDS49788 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||