InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Comt

Summary

InnateDB Gene

IDBG-141739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Comt

Gene Name

catechol-O-methyltransferase

Synonyms

Comt1; D16Wsu103e; D330014B15Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000326

Encoded Proteins

IDBP-141741

catechol-O-methyltransferase

IDBP-249253

catechol-O-methyltransferase

IDBP-542320

catechol-O-methyltransferase

IDBP-625713

catechol-O-methyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000093010:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:18406886-18426852

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000335	ENSMUSP00000000335
ENSMUST00000115609	ENSMUSP00000111272
ENSMUST00000147720	ENSMUSP00000121810
ENSMUST00000165430	ENSMUSP00000130077

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0007565	female pregnancy
GO:0007612	learning
GO:0007614	short-term memory
GO:0008210	estrogen metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0014070	response to organic cyclic compound
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0032496	response to lipopolysaccharide
GO:0032502	developmental process
GO:0035814	negative regulation of renal sodium excretion
GO:0042135	neurotransmitter catabolic process
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0045963	negative regulation of dopamine metabolic process
GO:0048265	response to pain
GO:0048609	multicellular organismal reproductive process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050668	positive regulation of homocysteine metabolic process
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome