Mus musculus Gene: Limk2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-139221.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Limk2 | ||||||||||||||||||||||
Gene Name | LIM motif-containing protein kinase 2 | ||||||||||||||||||||||
Synonyms | Limk-2 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020451 | ||||||||||||||||||||||
Encoded Proteins |
LIM motif-containing protein kinase 2
LIM motif-containing protein kinase 2
LIM motif-containing protein kinase 2
LIM motif-containing protein kinase 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182541:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:3344256-3409189 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Axon guidance pathway
Regulation of actin cytoskeleton pathway
Fc gamma R-mediated phagocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Sema4D induced cell migration and growth-cone collapse pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
EPH-Ephrin signaling pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Axon guidance pathway
Fc gamma R-mediated phagocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
CDC42 signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.124176 | ||||||||||||||||||||||
RefSeq | NM_001034030 NM_010718 NM_173053 XM_006514546 XM_006514547 XM_006514548 XM_006514549 XM_006514550 XM_006514551 XM_006514552 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS24358 CCDS24359 CCDS24360 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||