Version 5.4
Homo sapiens Gene: FOXM1
Summary
InnateDB Gene IDBG-12457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXM1
Gene Name forkhead box M1
Synonyms FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT
Species Homo sapiens
Ensembl Gene ENSG00000111206
Encoded Proteins
IDBP-12459
forkhead box M1
IDBP-12461
forkhead box M1
IDBP-12463
forkhead box M1
IDBP-590007
forkhead box M1
IDBP-586855
forkhead box M1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:2857681-2877040
Strand Reverse strand
Band p13.33
Transcripts
ENST00000342628 ENSP00000342307
ENST00000359843 ENSP00000352901
ENST00000361953 ENSP00000354492
ENST00000366362
ENST00000536066
ENST00000535350 ENSP00000442309
ENST00000538564 ENSP00000444541
ENST00000537018
ENST00000545049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0001570 vasculogenesis
GO:0001889 liver development
GO:0006281 DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049 cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046578 regulation of Ras protein signal transduction
GO:0051726 regulation of cell cycle
GO:0071156 regulation of cell cycle arrest
GO:0090344 negative regulation of cell aging
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000781 positive regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001517
View Gene Order
ENSBTAG00000015875
Not yet available
Pathways
NETPATH
REACTOME
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.239
RefSeq NM_001243088 NM_001243089 NM_021953 NM_202002 NM_202003 XM_005253676
HUGO
OMIM
CCDS CCDS8515 CCDS8516 CCDS8517
HPRD 03823
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca