Version 5.4
Homo sapiens Gene: MAPK6
Summary
InnateDB Gene IDBG-12347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK6
Gene Name mitogen-activated protein kinase 6
Synonyms ERK3; HsT17250; p97MAPK; PRKM6
Species Homo sapiens
Ensembl Gene ENSG00000069956
Encoded Proteins
IDBP-12349
mitogen-activated protein kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51952106-52067372
Strand Forward strand
Band q21.2
Transcripts
ENST00000261845 ENSP00000261845
ENST00000560802
ENST00000558063
ENST00000560254
ENST00000558100
ENST00000558841
ENST00000558891
ENST00000560774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 325 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 325 [view]
Protein-Protein 325 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042688
View Gene Order
ENSBTAG00000005865
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.411847 Hs.610447 Hs.713784
RefSeq NM_002748 XM_005254536 XM_005254537 XM_005254538 XM_005254539
HUGO
OMIM
CCDS CCDS10147
HPRD 04213
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca